Profhilo aka Time-reversing injection 逆時針 is an injectable skin remodelling treatment containing one of the highest concentrations of Hyaluronic acid (HA) in the market! Founded in Italy in 2015, it has made its way to our shores in 2020 and is especially good for people whose skin lacks elasticity and volume and in patients suffering from mild to moderate cases of skin laxity and fine lines.

Compared to traditional HA fillers which just plump up and fill wrinkles, the slow release of HA by Profhilo stimulates the production of collagen and elastin. It acts on different layers of the skin to stimulate fibroblasts. keratinocytes and adipocytes for healthier skin to allow for bio remodelling with improved elasticity and support. 

It is biocompatible, produced from highly pure grade HA produced by biofermentation, and absent from additives, therefore offering greater safety and reduced side effects.

 It’s patented Hybrid Cooperative complexes contain both high and low molecular weight HA which are thermally cross-linked, and free from BDDE (a common chemical cross-linking agent). This allows for a lower inflammatory response, lower viscosity and hence easier spreadability, allowing 10 injections points to cover the entire lower face or neck.

Profhilo is safer and is associated with less injection marks, risk of bruising compared to traditional skinboosters. The absence of chemical cross links or BDDE allows for greater biocompatibility in human skin, reducing the risk of granulomas (bumps under the skin) or inflammation. The 5 BAP points (bio-aesthetic points) have been specifically chosen because they are far away from major nerves and blood vessels. Intravascular injection of filler and injury to these structures is thus much lower.

Profhilo involves injections just below the skin surface over 2 sessions, 4 weeks apart. After injection, the HA quickly disperses without need for massage or risk of leaving lumps or nodules. The treatments can be repeated every 6 months as needed to maintain the results. 


ME Clinic Singapore is dedicated to serving our clients the full Korean aesthetic experience, within a chicly-decorated, glamorous but comfy space that will indulge your senses. Our hospitable staff will be ready to greet you with a warm cup of tea as soon as you arrive.


Our licensed consultant will examine your skin and note all visible skin problems, such as redness, lines and wrinkles, pore size, acne severity (if present), and scarring. After analyzing your skin concerns, the consultant will suggest a treatment plan to achieve your desired results.


The procedure starts with double cleansing to get rid of makeup, dirt, and excess sebum. An anesthetic cream is applied to minimize pain and discomfort. Profhilo is injected beneath the skin, penetrating very shallow depths. To repair the injured skin and hasten the healing process, we incorporate red light technology.


For faster recovery, we perform additional treatments that are unique to our clinic:

  • Cryotherapy to soothe and cool the skin
  • Stem Cell Mask to increase hydration and promote healing
  • LED light to calm the skin

Hyaluronic acid draws in water from your body and this effect can be seen within 3-5 days of treatment. The second phase (over the next few weeks), production of collagen and elastin is stimulated, with the added effect of skin tightening. 

You May Expect:

  • Hydrated skin
  • Softer skin
  • Improvements to skin tone

According to Ministry of Health regulations, we are unable to share any before and after shots or patient reviews.
However, do visit our clinic so we can provide you with more information and images on potential results.

You may experience some redness or swelling at the injection site that should dissipate within a couple of days or up to a week. All treatments at ME Clinic are performed by licensed doctors and trained medical professionals that have completed proper procedural training.

Contact us for more information.